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Chinese scientist edits twin human baby genes to prevent HIV infection

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6 years ago

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A Chinese scientist and professor named Dr. He Jiankui claimed this week that he edited the genes of recently born twin girls while they were embryos. Using a technique called CRISPR-Cas9, the gene responsible for allowing HIV to infect the body was altered to mimic a natural genetic variation in some humans that confers strong resistance to the virus. The father of the babies in the study is HIV positive, a fact which motivated the study and the family’s willingness to take part.

The study’s twins, referred to as “Lulu and Nana”, are said to be in excellent health, and the full details of the corresponding study promised to be provided for public review in the near future. Dr. He, who studied at Rice University in Texas and Stanford University in California, is expected to speak at the Second International Summit on Human Genome Editing in Hong Kong on Wednesday where further evidence may be presented. Thus far, none has been made available, although Dr. He’s previous work is well known to those in the field, giving certain merit to his claims.

The response to Dr. He’s announcement has, thus far, been overwhelmingly negative along with the validity of the claims being questioned. The ethics of gene editing in babies is decidedly set against the practice in the global scientific community, and a significant number of organizations have issued public statements strongly condemning the professor’s work. The Chinese government has also since ordered an inquiry. While an explicit ban on gene editing on embryos intended for reproduction does not exist in the country, strict ethical guidelines recommend strongly against the practice.

Dr. He in his video announcement of the gene edited twins. | Credit: The He Lab

Additionally, Dr. He adamantly denies that his research and work in gene editing serves the purpose of the infamous “designer baby” concept. “For forty years, regulations and morals have developed together with IVF [and gene editing is another] advancement…only meant to help a small number of families,” he stated in his video published November 25th. In an interview with the AP, he defined his goal as bestowing traits that resist future infections from diseases like HIV, the AIDS virus.

The process involved in editing the twin girls’ DNA, as described, began as a regular In Vitro Fertilization (IVF) process wherein the mother’s eggs were fertilized by the father’s sperm to create an embryo in a laboratory environment. At that stage, a CRISPR/Cas9 protein with gene editing instructions was introduced to amend the embryo DNA, and those embryos were subsequently implanted in the mother. Dr. He has claimed that the resulting genomes were assessed at the embryonic stage, during pregnancy, and after birth to confirm that the intended gene alone was changed.

A visual representation of CRISPR-Cas9 gene editing. | Credit: NIH

The hospital claimed to have approved Dr. He’s research, Shenzhen Harmonicare Women’s and Children’s Hospital, has denied having a relationship with Dr. He or any involvement in the experiment. They have also lodged a police report in this regard. Additionally, Southern University of Science and Technology, the university where Dr. He is employed, stated that the professor has been on unpaid leave since February 1, 2018, thus the research involved with the twins was not affiliated with the school.

One of the primary concerns with editing genomes at the embryo level is the long-term impact on both the humans in question and their offspring who will inherit the modified genes. The edited DNA would eventually enter the general population as it passed on through generations. In this study, CCR5, a gene used to make a protein HIV needs to enter cells, was disabled in the twins’ DNA, an edit which effectively shuts off the “gateway” through which the virus infects the body. Although no unintended consequences have yet been observed in this example, scientists overall point to years of study still needed before clinical treatment can ethically be conducted.

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One of the ethical guidelines involved in gene editing is restricting its use to only addressing medical needs which cannot be effectively treated through other means. In denouncing the driver of Dr. He’s study, specifically in addressing HIV via gene editing, safe-sex was recommended as a preventative along with current medical treatments in the case of infection by the director of the Oxford Uehiro Centre for Practical Ethics at the University of Oxford. Opposing the opinion of the medical community, however, a recent study by the Sun Yat-Sen University in China found that around 60% of Chinese people have a favorable view of gene editing for disease therapy. Professor He has also pointed to the discrimination faced by Chinese people with HIV as further motivation for his controversial work.

Watch the below video He Jianjui published announcing the gene surgery:

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Accidental computer geek, fascinated by most history and the multiplanetary future on its way. Quite keen on the democratization of space. | It's pronounced day-sha, but I answer to almost any variation thereof.

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Elon Musk seemingly confirms Cybertruck gift to 13-year-old cancer fighter

Diagnosed in 2018 with a rare form of brain and spine cancer with no cure, the teen has undergone 13 surgeries by the time he was 12.

Published

1 week ago

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March 6, 2025

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Credit: Tesla

Elon Musk has seemingly confirmed that he will be sending a Tesla Cybertruck to 13-year-old Devarjaye “DJ” Daniel, a 13-year-old Houston boy fighting brain cancer. The teen was recognized as an honorary Secret Service member by U.S. President Donald Trump during his address to Congress on Tuesday. 

A Chance Meeting

The Tesla CEO’s Cybertruck pledge was mentioned during DJ’s short interview with CNN’s Kaitlan Collins. When Collins asked the 13-year-old what he told the Tesla CEO, DJ answered that he asked for a Cybertruck.

“I said, ‘can you do me a big favor, when you get back to Houston can you send us a Cybertruck down there?’” the cancer fighter stated.

Daniel noted that Musk responded positively to his request, which was highlighted by Collins in a post on X. Musk responded to the post with a heart emoji, suggesting that he really will be sending a Cybertruck to the 13-year-old cancer fighter.

Teen’s Cancer Battle Inspires

Diagnosed in 2018 with a rare form of brain and spine cancer with no cure, Daniel has undergone 13 surgeries by the time he was 12. During his speech, Trump highlighted the 13-year-old’s long battle with his disease. 

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“Joining us in the gallery tonight is a young man who truly loves our police. The doctors gave him five months at most to live. That was more than six years ago. Since that time, DJ and his dad have been on a quest to make his dream come true,” Trump stated.

Daniels officially received an honorary badge from U.S. Secret Service Director Sean Curran, to much applause during the event.

Surprisingly Partisan

While Daniels’ story has been inspiring, Trump’s focus on the 13-year-old cancer fighter has received its own fair share of criticism. MSNBC host Nicolle Wallace, while referencing Daniels’ love for law enforcement, noted that she is hoping the 13-year-old never has to defend the U.S. capitol against Trump supporters. “If he does, I hope he isn’t one of the six who loses his life to suicide,” Wallace stated.

Anti-Musk and Trump accounts on X have also thrown jokes at the cancer fighter’s honorary badge, with some dubbing the 13-year-old as a “DEI hire” that should be looked into by DOGE.

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Tesla owner highlights underrated benefit of FSD Supervised

Published

1 month ago

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January 31, 2025

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Credit: Tesla

Elon Musk has been pretty open about the idea of FSD being the difference maker for Tesla’s future.

If Tesla succeeds in achieving FSD, it could become the world’s most valuable company. If it doesn’t, then the company would not be able to reach its optimum potential.

FSD Supervised’s safety benefits:

  • But even if FSD is still not perfect today, FSD Supervised is already making a difference on the roads today.
  • This was highlighted in Tesla’s Q4 2024 Vehicle Safety Report.
  • As per Tesla, it recorded one crash for every 5.94 million miles driven in which drivers were using Autopilot technology.
  • For comparison, the most recent data available from the NHTSA and FHWA (from 2023) showed that there was one automobile crash every 702,000 miles in the United States. 

FSD user’s tale:

  • As per an FSD user’s post on social media platform X, FSD Supervised was able to help him drive a relative to a medical facility safely even if he was exhausted.
  • During the trip, the driver only had to monitor FSD Supervised’s performance to make sure the Tesla operated safely.
  • In a vehicle without FSD, such a trip with an exhausted driver would have been quite dangerous. 
  • “This morning, Tesla FSD proved to be an absolute godsend. I had to take my brother-in-law to the hospital in Sugar Land, TX, which is 40 miles away, at the ungodly hour of 4 AM. Both of us were exhausted, and he was understandably anxious about the surgery.
  • “The convenience of sending the hospital’s address directly from my iPhone to my Tesla while still inside my house, then just a single button press once inside, and 40 miles later we were precisely in front of the hospital’s admissions area.This experience really underscores just how transformative this technology can be for society,” Tesla owner JC Christopher noted in his post.

Don’t hesitate to contact us with news tips. Just send a message to simon@teslarati.com to give us a heads up.

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Tesla Optimus “stars” in incredible fanmade action short film

Published

2 months ago

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January 14, 2025

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Credit: @SoKrispyMedia/YouTube

There are few things that prove an enthusiast’s love towards a company more than a dedicated short film. This was highlighted recently when YouTube’s SoKrispyMedia posted a 10-minute action movie starring Optimus, Tesla’s humanoid robot, as well as several of the company’s most iconic products. 

The video: 

  • Shot like a Hollywood action flick, the video featured a rather humorous plot involving a group of thieves that mistakenly targeted a Tesla Model 3 driver. 
  • The Model 3 driver then ended up speaking to Tesla for assistance, and some high-octane and high-speed hijinks ensued.
  • While the short film featured several Tesla products like the Model 3, Superchargers, and the Cybertruck, it is Optimus that truly stole the show.
  • Optimus served several roles in the short film, from an assistant in a Tesla office to a “robocop” enforcer that helped out the Model 3 driver.

Cool inside jokes: 

  • The best Tesla videos are those that show an in-depth knowledge of the company, and SoKrispyMedia definitely had it. 
  • From the opening scenes alone, the video immediately poked fun at TSLA traders, the large number of gray Tesla owners, and the fact that many still do not understand Superchargers.
  • The video even poked fun at Tesla’s software updates, as well as how some Tesla drivers use Autopilot or other features without reading the fine print in the company’s release notes.
  • The video ended with a tour de force of references to Elon Musk products, from the Tesla Cybertruck to the Boring Company Not-a-Flamethrower, which was released back in 2018.

Check out SoKrispyMedia’s Tesla action short film in the video below.

Don’t hesitate to contact us with news tips. Just send a message to simon@teslarati.com to give us a heads up.

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