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Researchers fold DNA into world’s smallest tic-tac-toe game
Researchers from The Qian Lab at the California Institute of Technology (Caltech) have used DNA folding, also known as DNA origami, to create the world’s tiniest game of tic-tac-toe. Since its creation in 2006 by Paul Rothemund, this technique has opened up the possibility of building “smart” programmable materials on the nanoscale using these self-assembling molecules. By capitalizing on DNA’s inherent tendency to pair with complementary bases that form its building blocks – guanine (G) pairs with cytosine (C) and adenine pairs (A) with thymine (T) – scientists can take a single strand of DNA and mix in smaller pieces that only attach to certain portions of the longer strand, called ‘staples’, pulling the single strand into the desired form. The team at Caltech has advanced this technique by enabling the forms to be changed, or “reprogrammed”, at will, enabling previously programmed DNA to be upgraded if needed. These advancements may help lead the way in areas such as developing DNA computers and the creation of new chemicals.
Over a period of around six days, each turn taking time for the DNA to reassemble, members of the Caltech research team played out the classic tic-tac-toe game, crowning ‘X’ as the winner. There were two techniques used: First, a set of DNA tiles (squares) were assembled to form the board. The tile assembly was accomplished using general folding techniques now common in the field and previously demonstrated on an advanced scale with the team’s Mona Lisa project wherein numerous tiles were assembled into the famous portrait. Second, the technique of ‘displacement’ allowed team members to insert new tiles, programmed with an ‘X’ or ‘O’ shape for a specific place on the board, to kick out the blank tile previously there. The full details of their accomplishment were published in the December 18, 2018 edition of the journal Nature Communications.
While DNA is generally known to contain the genetic instructions for building living things, as a molecule, it makes a useful tool for building tiny objects. The original shapes formed with the origami technique were 2D – smiley faces, stars, etc. However, in recent years, scientists have moved into increasingly complex 3D shapes – boxes, triangles, and even rabbits. The Qian Lab has additionally developed software that enables other scientists to easily program 2D assemblies from an image using the fractal methods demonstrated in the Mona Lisa project. The protocols output by the software can even be read by lab robots, completing the automation circle.
An animation of the Caltech team’s tic-tac-toe game:
One of the other long-term goals of DNA origami is to develop DNA robots or machines that can be programmed to act in specific ways inside the body. For example, a drug intended to kill cancerous tumor cells could be encapsulated in a DNA-folded box and only opened when tumor cell DNA matched its sequence-based lock. Combining the developments in artificial intelligence for identifying and predicting disease with the potential targeted delivery systems demonstrated with DNA origami, the future of technology in medicine is promising.
Watch the below video by Nature for an overview of the DNA folding process:
Elon Musk
Elon Musk’s xAI, creator of Grok and Grokipedia, celebrates its third birthday
xAI Memphis highlighted several of its milestones over the years in its celebratory post.
Elon Musk’s artificial intelligence startup xAI has marked its third anniversary. The update was shared in a post from the xAI Memphis account on social media platform X.
xAI Memphis highlighted several of its milestones over the years in its celebratory post.
As per xAI, it has built three massive data centers in the city, launched a coherent cluster of 330,000 GBs, created over 3,000 jobs, and paid over $30 million in taxes to local communities.
xAI’s Memphis operation has become a key part of the company’s infrastructure as the company works to train and deploy its Grok artificial intelligence models. Elon Musk has been quite optimistic about Grok’s potential, noting in the past that the large language model might have a shot at achieving artificial general intelligence (AGI).
xAI’s Memphis’ crown jewel is its Colossus supercomputer cluster. The project was announced in 2024 and has since become the home of one of the world’s largest AI compute facilities. The first phase of Colossus reached its initial 100,000 GPU operational milestone in just 122 days, or just about four months.
Industry figures such as Nvidia CEO Jensen Huang have praised the facility, noting that projects of similar scale typically take two to four years to complete.
xAI has cited Memphis’ central location, skilled workforce, and industrial infrastructure as key reasons for selecting the city as the home of its AI training operations. The company has also emphasized plans to expand the site further as it scales compute capacity for Grok and future AI models.
News
Tesla Sweden’s Megapack Supercharger near Arlanda continues to aggravate IF Metall union
The charging site, located in Arlandastad outside Stockholm, appears to be operating despite ongoing union blockade measures tied to Tesla’s labor dispute in the country.
Tesla Sweden’s Megapack-powered Supercharger station near Arlanda Airport has continued to aggravate Swedish labor union IF Metall. The charging site, located in Arlandastad outside Stockholm, appears to be operating despite ongoing union blockade measures tied to Tesla’s labor dispute in the country.
Comments about the site were shared by IF Metall representatives in remarks to Swedish publication CarUp.
The Arlandastad location includes eight Tesla Superchargers powered by a Megapack battery system. Unlike traditional charging stations that rely on direct grid connections, the site uses a large battery installation to store electricity and power the chargers.
According to the Swedish publication, the setup allowed the station to come online despite sympathy measures from Sweden’s electricians’ union, which has attempted to prevent companies from cooperating with Tesla as part of the broader labor conflict.
IF Metall press manager Jesper Pettersson indicated that the union was not aware that the Superchargers had already been connected and activated.
“We do not know the details around this. But it is further proof of how Tesla systematically finds loopholes to circumvent the sympathy measures through active strikebreaking. Every time this happens it gives us reason to sharpen our conflict measures,” Pettersson said.
Union representatives also noted that the Megapack appears to be charged using electrical cables routed through nearby terrain, though the exact power source remains under review.
The Megapack-powered site has then prompted questions from Swedish labor unions about how electricity is being supplied to the system.
IF Metall has submitted a report to Sweden’s Energy Market Inspectorate asking the regulator to review whether the electricity supply arrangement complies with national regulations. The Megapack is reportedly charged using electricity from a local company, though the provider has not been publicly identified.
Peter Lydell, an ombudsman at IF Metall, previously stated that Swedish law limits electricity trading to companies with proper authorization.
“The legislation states that only companies that engage in electricity trading may supply electricity to other parties. You may not supply electricity without a permit, then you are engaging in illegal electricity trading. That is why we have reported this…
“This is about a company that helps Tesla circumvent the conflict measures that exist. It is clear that it is troublesome and it can also have consequences,” Lydell said.
IF Metall and Tesla Sweden’s conflict has been going on for over two years now.
Elon Musk
Starbase after dark: Musk’s latest photo captures a Spaceport on the brink of history
SpaceX’s Starbase city in Boca Chica, Texas is rapidly transforming the southern tip of the Lone Star State into one of the most ambitious launch complexes in history.
A striking nighttime photograph of SpaceX’s Starbase facility in Boca Chica, Texas, shared recently by Elon Musk on X, offers a dramatic glimpse of an operation that is rapidly transforming the southern tip of the Lone Star State into one of the most ambitious launch complexes in history.
The most immediately visible change in the photo is the presence of two fully erected Starship launch towers dominating the coastal skyline. The second orbital launch pad, known as Pad B, now features its fully erected tower, OLIT-3, which stands approximately 474 feet tall and incorporates an integrated water-cooled flame trench designed to minimize damage and reduce turnaround time between launches. The dual-tower silhouette against the night sky signals a decisive shift from experimental testing facility to high-cadence launch operations.
Grok Image concept of Elon Musk’s latest Starbase photo via X
Back at Starbase, Pad 2 is approaching hardware completion, with upgraded chopstick arms, a new chilldown vent system, and all 20 hold-down arms now fitted with protective doors to shield them from the intense exhaust of up to 33 Raptor 3 engines, according to a deeper dive by NASASpaceFlight.
SpaceX has also received approval to nearly double the footprint of the Starbase launch site, with groundwork already underway to add LNG liquefaction plants, expanded propellant storage, and additional ground support infrastructure.
The photo also carries a milestone civic dimension. Starbase officially became a Texas city in May 2025 after a community vote, with SpaceX employees elected as mayor and commissioners of the newly incorporated municipality. That legal status streamlines launch approvals and gives SpaceX direct control over local infrastructure decisions.
The FAA has approved an increase in launches from Starbase in Texas from five to twenty-five per year, clearing the runway for the kind of flight frequency needed to fulfill Starship’s ultimate mission of ferrying cargo and crew to the Moon, servicing the Department of Defense, deploying next-generation Starlink satellites, and eventually establishing Elon Musk’s long sought after goal of a self-sustaining human presence on Mars.
Seen from above in the dark, Starbase looks less like a test site and more like a spaceport.
Elon Musk’s xAI, creator of Grok and Grokipedia, celebrates its third birthday
Tesla Sweden’s Megapack Supercharger near Arlanda continues to aggravate IF Metall union
