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Chinese scientist edits twin human baby genes to prevent HIV infection

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A Chinese scientist and professor named Dr. He Jiankui claimed this week that he edited the genes of recently born twin girls while they were embryos. Using a technique called CRISPR-Cas9, the gene responsible for allowing HIV to infect the body was altered to mimic a natural genetic variation in some humans that confers strong resistance to the virus. The father of the babies in the study is HIV positive, a fact which motivated the study and the family’s willingness to take part.

The study’s twins, referred to as “Lulu and Nana”, are said to be in excellent health, and the full details of the corresponding study promised to be provided for public review in the near future. Dr. He, who studied at Rice University in Texas and Stanford University in California, is expected to speak at the Second International Summit on Human Genome Editing in Hong Kong on Wednesday where further evidence may be presented. Thus far, none has been made available, although Dr. He’s previous work is well known to those in the field, giving certain merit to his claims.

The response to Dr. He’s announcement has, thus far, been overwhelmingly negative along with the validity of the claims being questioned. The ethics of gene editing in babies is decidedly set against the practice in the global scientific community, and a significant number of organizations have issued public statements strongly condemning the professor’s work. The Chinese government has also since ordered an inquiry. While an explicit ban on gene editing on embryos intended for reproduction does not exist in the country, strict ethical guidelines recommend strongly against the practice.

Dr. He in his video announcement of the gene edited twins. | Credit: The He Lab

Additionally, Dr. He adamantly denies that his research and work in gene editing serves the purpose of the infamous “designer baby” concept. “For forty years, regulations and morals have developed together with IVF [and gene editing is another] advancement…only meant to help a small number of families,” he stated in his video published November 25th. In an interview with the AP, he defined his goal as bestowing traits that resist future infections from diseases like HIV, the AIDS virus.

The process involved in editing the twin girls’ DNA, as described, began as a regular In Vitro Fertilization (IVF) process wherein the mother’s eggs were fertilized by the father’s sperm to create an embryo in a laboratory environment. At that stage, a CRISPR/Cas9 protein with gene editing instructions was introduced to amend the embryo DNA, and those embryos were subsequently implanted in the mother. Dr. He has claimed that the resulting genomes were assessed at the embryonic stage, during pregnancy, and after birth to confirm that the intended gene alone was changed.

A visual representation of CRISPR-Cas9 gene editing. | Credit: NIH

The hospital claimed to have approved Dr. He’s research, Shenzhen Harmonicare Women’s and Children’s Hospital, has denied having a relationship with Dr. He or any involvement in the experiment. They have also lodged a police report in this regard. Additionally, Southern University of Science and Technology, the university where Dr. He is employed, stated that the professor has been on unpaid leave since February 1, 2018, thus the research involved with the twins was not affiliated with the school.

One of the primary concerns with editing genomes at the embryo level is the long-term impact on both the humans in question and their offspring who will inherit the modified genes. The edited DNA would eventually enter the general population as it passed on through generations. In this study, CCR5, a gene used to make a protein HIV needs to enter cells, was disabled in the twins’ DNA, an edit which effectively shuts off the “gateway” through which the virus infects the body. Although no unintended consequences have yet been observed in this example, scientists overall point to years of study still needed before clinical treatment can ethically be conducted.

One of the ethical guidelines involved in gene editing is restricting its use to only addressing medical needs which cannot be effectively treated through other means. In denouncing the driver of Dr. He’s study, specifically in addressing HIV via gene editing, safe-sex was recommended as a preventative along with current medical treatments in the case of infection by the director of the Oxford Uehiro Centre for Practical Ethics at the University of Oxford. Opposing the opinion of the medical community, however, a recent study by the Sun Yat-Sen University in China found that around 60% of Chinese people have a favorable view of gene editing for disease therapy. Professor He has also pointed to the discrimination faced by Chinese people with HIV as further motivation for his controversial work.

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Watch the below video He Jianjui published announcing the gene surgery:

Accidental computer geek, fascinated by most history and the multiplanetary future on its way. Quite keen on the democratization of space. | It's pronounced day-sha, but I answer to almost any variation thereof.

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Elon Musk

How to use Grok Bot to block spam calls and texts

Musk told users to ask Grok Bot to scrub their phone numbers from spam lists.

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Elon Musk has a new use case for Grok Bot, and it is the spam call. On Thursday he replied to an X user named Arash with a short instruction: “Ask your @Grok @Bot to remove your phone number from spam call & text lists!” Arash had said he got tired of the calls, had an AI bot find his number on listing sites and file removal requests, and packaged the process as a free skill for others.

The skill is called Spam-Call Scrubber, which is described to find a phone number on people search sites and data brokers, submits the opt outs, completes the confirmation emails those sites send back, and rechecks on a schedule the user picks. Using it requires the Grok Bot app. The pitch is time saved, since most broker opt outs sit behind separate forms on separate sites.



Musk said Grok Bot now gives each bot its own email address, and that it can detect scam emails. On Thursday he also said SpaceX would make users whole if the bot botches a purchase or leaks a card, then told users to shop away from Amazon after the retailer blocked the agent, as Teslarati reported. The terms of service we reviewed at the time put responsibility for what an agent does on the user.

For Tesla owners, Grok Bot is not just a phone app. Tesla brought Grok Bot into its vehicles on September 22, and we argued earlier this week that the Cybercab’s real advantage may be the errands it runs during a ride. Every Cybercab and the rest of the Model Y Robotaxi fleet has it enabled. The more routine tasks like this one become, the more a rider has reason to hand over something personal in the back seat.

The new Spam-Call Scrubber skill can be downloaded for free and works on sites that honor removal requests, while noting that listings can reappear, and illegal robocallers do not check any registry. Whether Spam-Call Scrubber cuts anyone’s call volume is something the first wave of users will find out, and Musk’s endorsement guarantees that wave is coming.

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Tesla Cybercab and Robotaxi’s real advantage won’t be the ride service

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Concept art of a Tesla Cybercab in Las Vegas Strip as rendered via Grok

For a century, the car has asked the same thing of its owner, which is basically to pay attention. Even the best ride-hailing app like Uber or Lyft only moved the problem into someone else’s hands. You stopped driving, but you still sat in a stranger’s car, while half listening, and wondering whether to take a phone call in the car without being rude. The Cybercab has no wheel, no pedals and no driver. With Grok @bot now live inside it, it becomes something else entirely, and I think that matters more than the fleet count that everyone is tracking.

Grok @bot is an agent, not a voice assistant. A rider signs in once, and from then on can say what they need and watch it happen. Order dinner from a favorite restaurant. Fill the grocery cart. Move money, answer email, adjust a calendar, push a work project forward. Tesla engineer Yun-Ta Tsai confirmed it is enabled across every Cybercab and the rest of the Model Y fleet, and Tesla’s own pitch is that Full Self-Driving handles the commute while Grok handles the errands.

Think about what that does to a thirty minute ride. Uber sells you a trip, while Waymo sells you the same trip in a more private setting. Tesla is selling the thirty minutes themselves, returned to you with an assistant attached. Errands that used to eat a Saturday get done between pickup and drop off. The ride stops being dead time between two places and becomes a place of its own.

Tesla integrates Grok Bot into its vehicles for the ultimate personal assistant

Best of all, your Bots follow you into any Cybercab, and presumably your own Tesla, then logs you out automatically when you step out. Anyone can bolt a chatbot onto a screen, but much harder to own the vehicle, the autonomy stack and the assistant at once. It also quietly ties SpaceX’s Super Intelligence business to Tesla’s fleet, after Tesla converted its xAI stake into SpaceX equity. The relationship between those two companies is getting harder to describe as separate.

This is also where the hard questions start, because an agent that can spend your money in a vehicle other people also ride in needs some answers. How does it handle a voice it shouldn’t trust? What gets recorded, who can see it, and for how long? What happens when a rider leaves halfway through a task?

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If Tesla gets those answers right, the scoreboard changes. We have been counting Cybercabs and wait times. The more telling number may be what riders accomplish per trip. That is data almost no one else will ever have, and it is the real reason to watch Grok @bot.

What do you think? Leave me a comment.

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Tesla’s mirrorless Cybercab will give riders a visibility upgrade

Tesla engineer confirms Cybercab update letting riders pull up rear and repeater cameras on demand.

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Tesla Cybercab camera visibility for passengers (Credit: Dan Burkland via X)
Tesla Cybercab camera visibility for passengers (Credit: Dan Burkland via X)

Tesla is working on a Cybercab update that would let passengers pull up the vehicle’s rear and side cameras on demand, and the request came straight from a rider.

The exchange played out on X late Friday. Cybercab rider Dan Burkland shared photos of the two-seater’s cabin screen after an evening ride, praised the UI team’s work, and left one request: let riders open the rear and repeater cameras whenever they want, “especially for peace of mind.” Tesla UI software engineer Evan (@CarCoder) answered with two words: “In development.”

The idea fits a pattern Teslarati has tracked since public rides began. Days after paid Cybercab service opened in Austin, Tesla sent riders a survey that asked them to rate the touchscreen, the app and the cabin, and to pick the features they wanted most. We reported on that survey in September, and a camera view is the kind of small software change Tesla can push quickly if riders keep asking.

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It also speaks to something unique about the vehicle. With no steering wheel, no pedals and no driver, passengers have no mirror to check and no way to see behind them. The hardware is clearly built for camera awareness, from the repeater cameras to the rear camera. Letting a passenger look through those same cameras would give a nervous first time rider a way to confirm what is around the car.

The timing matters because the fleet is growing fast. Tesla’s Robotaxi account said on Saturday that more than 300 Cybercabs are now serving Austin, an eightfold increase in 30 days, and Tesla AI chief Ashok Elluswamy named Dallas as the next city. More cars and more cities mean more people riding in a driverless vehicle for the first time, which is exactly when small trust features carry weight.

For now, the feature is confirmed only as in development. If Tesla follows its usual pattern with Cybercab software, riders could see it appear in a point release without any announcement, and Teslarati will watch for it.

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